Table 2.
Phenyl adamantyl ureas with large substituents
| ||||
|---|---|---|---|---|
| ID # | R | MIC μg/ml | cLogP | |
| 32 | p |
|
0.1 | 5.9 |
| 33 | m |
|
0.3 | 6.1 |
| 34 | p |
|
0.6 | 6.0 |
| 35 | p |
|
1.8 | 5.3 |
| 36 | m |
|
2.4 | 5.4 |
| 37 | m |
|
2.5 | 4.0 |
| 38 | m |
|
3.4 | 5.9 |
| 39 | m |
|
5.7 | 5.4 |
| 40 | p |
|
>25 | 4.3 |
| 41 | m |
|
21 | 4.0 |
| 42 | o |
|
21 | 4.0 |
| 43 | o |
|
21 | 3.9 |
| 44 | p |
|
21 | 4.0 |
| 45 | m |
|
>30 | 3.2 |
| 46 | p |
|
>30 | 4.0 |
| 47 | m |
|
32 | 3.9 |
| 48 | p |
|
39 | 5.4 |
| 49 | m |
|
>33 | 3.4 |
| 50 | p |
|
>37 | 2.7 |
| 51 | p |
|
>44 | 3.8 |
| 52 | m |
|
44 | 3.5 |
| 53 | p |
|
62 | 3.4 |
| 54 | p |
|
66 | 5.3 |
| 55 | p |
|
>68 | 3.8 |