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. Author manuscript; available in PMC: 2013 May 15.
Published in final edited form as: Bioorg Med Chem. 2012 Mar 31;20(10):3255–3262. doi: 10.1016/j.bmc.2012.03.058

Table 4.

Efficacy of two adamantyl ureas in mice

Group: Number of mice Lung Log10CFU Spleen Log10CFU
Day 1 post aerosol infection 3 1.85 ± 0.14 NA
Day 15 post aerosol infection 5 7.42 ± 0.08 5.53 ± 0.22
Day 24 post aerosol infection (no drug treatment) 3 8.86 ± 0.02 7.30 ± 0.09
Day 24 post aerosol infection Captisol only (OPD oral) 4 8.77 ± 0.18 7.06 ± 0.13
Day 24 post aerosol infection treated with 6 (150 mg/kg BID oral) 5 8.77 ± 0.12 7.31 ± 0.13
Day 24 post aerosol infection treated with 7 (150 mg/kg BID oral) 4 8.74 ± 0.12 7.33 ± 0.02
Day 24 post aerosol infection treated with INH (25 mg/kg OPD oral) 5 5.41 ± 0.06a 3.63 ± 0.13
a

Significantly lower than day 24 untreated control (p < 0.05)