Table 1.

Performance of Various MIEC-SVM Models for the SH3 Class-II Binding Peptides^a

model	MIECsb	SEtrain (%)	SPtrain (%)	SEtest (%)	SPtest (%)	Q+ (%)	Q+ (%)	C
	SH3-peptide MIECs
1	ΔEvdw, ΔEele	90.2	87.0	84.9	86.7	24.2	99.1	0.409
2	ΔEpolarc, ΔEnonpolarc	86.4	85.0	82.7	84.7	21.3	99.0	0.370
3	ΔEvdw, ΔEele, ΔGGB	90.2	87.3	85.5	86.9	24.6	99.2	0.415
4	ΔEvdw, ΔEele, ΔGGB, ΔGsa	90.5	87.7	86.2	87.3	25.3	99.2	0.425
	SH3-peptide MIECs and peptide adjacent residue MIECs
5	ΔEvdw, ΔEele	90.7	90.2	85.0	89.9	29.7	99.2	0.465
6	ΔEpolar, ΔEnonpolar	90.3	90.3	85.1	90.0	29.9	99.2	0.467
7	ΔEvdw, ΔEele, ΔGGB	90.4	90.5	84.4	90.2	30.1	99.1	0.467
8	ΔEvdw, ΔEele, ΔGGB, ΔGsa	92.8	91.0	87.3	90.7	32.0	99.3	0.494
	SH3-peptide MIECs, peptide adjacent residue MIECs and peptide residue internal energies
9	ΔEvdw, ΔEele	93.6	90.9	88.6	90.6	32.0	99.4	0.499
10	ΔEpolar, ΔEnonpolar	93.1	91.8	87.9	91.4	33.9	99.3	0.514
11	ΔEvdw, ΔEele, ΔGGB	95.2	91.6	90.2	91.2	34.0	99.5	0.523
12	ΔEvdw, ΔEele, ΔGGB, ΔGsa	95.6	92.4	90.1	92.1	36.3	99.5	0.542

^aRBF kernel was used in SVM.

^bΔE_vdw, ΔE_ele, ΔG_GB, ΔG_SA are van der Waals, electrostatic, polar contribution to desolvation, and nonpolar contribution to desolvation, respectively.

^cΔG_polar = ΔE_ele + ΔG_GB, ΔG_nonpolar = ΔE_vdw + ΔG_SA