Table 2.

Performance of Various MIEC-SVM Models for the SH3 Class-I Binding Peptides^a

model	MIECsb	SEtrain (%)	SPtrain (%)	SEtest (%)	SPtest (%)	Q+ (%)	Q+ (%)	C
	SH3-peptide MIECs
1	ΔEvdw, ΔEele	78.2	89.5	71.7	89.1	30.3	98.0	0.415
2	ΔEpolarc, ΔEnonpolarc	72.2	89.5	66.6	89.2	28.9	97.6	0.385
3	ΔEvdw,ΔEele, ΔGGB	79.3	89.1	73.4	88.8	30.1	98.1	0.419
4	ΔEvdw,ΔEele,ΔGGB, ΔGSA	80.3	89.7	74.2	89.4	31.6	98.1	0.435
	SH3-peptide MIECs and SH3 residue–residue MIECs
5	ΔEvdw, ΔEele	85.0	91.2	79.7	90.9	36.6	98.5	0.498
6	ΔEpolar, ΔEnonpolar	85.7	90.5	80.2	90.2	35.1	98.6	0.487
7	ΔEvdw, ΔEele, ΔGGB	90.8	91.2	86.3	90.9	38.3	99.0	0.537
8	ΔEvdw, ΔEele, ΔGGB, ΔGSA	92.1	91.7	87.9	91.3	40.1	99.1	0.558
	SH3-peptide MIECs, SH3 residue–residue MIECs and peptide residue internal energies
9	ΔEvdw, ΔEele	90.5	93.6	85.7	93.3	45.7	99.0	0.595
10	ΔEpolar, ΔEnonpolar	89.8	93.7	84.7	93.3	45.6	98.9	0.589
11	ΔEvdw, ΔEele, ΔGGB	93.2	94.1	89.2	93.8	48.6	99.2	0.630
12	ΔEvdw, ΔEele, ΔGGB, ΔGSA	94.1	94.8	90.4	94.5	51.9	99.3	0.659

^aRBF kernel was used in SVM.

^bΔE_vdw, ΔE_ele, ΔG_GB, ΔG_SA are van der Waals, electrostatic, polar contribution to desolvation, and nonpolar contribution to desolvation, respectively.

^cΔG_polar = ΔE_ele + ΔG_GB, ΔG_nonpolar = ΔE_vdw + ΔG_SA.