Figure 2. IFN-γ responses to M. leprae antigens in PBMC from EChigh and EClow in Brazil.
IFN-γ production (corrected for background values) induced using PHA (A), M. leprae (B) or ML2478 recombinant protein (C) in 6 day cultures of PBMC from healthy individuals from an area of Fortaleza, Brazil with low (EClow; prevalence <0.2/10,000; n=10) or high (EChigh; prevalence > 4/10,000; n=10) leprosy prevalence, healthy household contacts (HHC) of MB leprosy patients and TT/BT patients. Median values for each group are indicated by horizontal lines. Background values were <20 pg/ml.