WT, TLR2−/−, TLR4−/−, TLR9−/−, and MyD88−/− mice (n = 10 in each case) were infected with P. yoelii. A and B, Blood parasitemia was measured every 2 days after infection and mean parasitemia in survived animals are plotted. C and D, The infected mice were monitored twice daily and their survival rates are plotted. Experiments were performed two times. The letters, a, b and c, denote the statistical significance of parasitemia and survival rates between TLR9−/− or MyD88−/− mice and infected WT mice. a, p <0.001; b, p <0.01; c, p <0.05.