Table 2. Differentially regulated inflammatory pathway genes in kidneys from chronically hypoxic mice.
Relative expression levels of genes assigned to inflammatory pathways that were at least ≥ 1.5 fold up- or down-regulated and had less than 10% FDR (total of 1170 probes and 912 genes) in kidneys from mice with mutated β–hemoglobin (Hbbth3/th3) compared to wild type littermates. Inflammatory pathway genes were considered those genes with ontologies of: Inflammatory response, activation of plasma proteins involved in acute inflammatory response, cytokine activity, and chemokine activity (http://david.abcc.ncifcrf.gov/).
| Gene | Description | Entrez Gene ID | Fold Induction |
|---|---|---|---|
| Ighg | Immunoglobulin heavy chain (gamma polypeptide) | BC092269 | −5.5 |
| Cxcl9 | chemokine (C-X-C motif) ligand 9 | NM_008599 | −3.5 |
| Cxcl10 | chemokine (C-X-C motif) ligand 10 | NM_021274 | −2.9 |
| Ccl2 | chemokine (C-C motif) ligand 2 | NM_011333 | −2.5 |
| Ccr2 | chemokine (C-C motif) receptor 2 | NM_020008 | −2.4 |
| Cxcr3 | Chemokine (C-X-C motif) receptor 3 | NM_009910 | −2.1 |
| Clec7a | C-type lectin domain family 7, member a | NM_020008 | −2.0 |
| C2ta | class II transactivator | NM_007575 | −1.9 |
| C8a | complement component 8, alpha polypeptide | NM_146148 | −1.9 |
| Ltb | lymphotoxin B | NM_008518 | −1.9 |
| Serpinf2 | serine (or cysteine) peptidase inhibitor, clade F, member 2 | NM_008878 | −1.9 |
| Cd74 | CD74 antigen | NM_001042605 | −1.9 |
| Ly86 | lymphocyte antigen 86 | NM_010745 | −1.8 |
| Mbl1 | mannose binding lectin (A) | NM_010775 | −1.8 |
| Prlr | Prolactin receptor | NM_011169 | −1.8 |
| Ccl7 | chemokine (C-C motif) ligand 7 | NM_013654 | −1.7 |
| Fn1 | fibronectin 1 | NM_010233 | −1.7 |
| Il16 | interleukin 16 | NM_010551 | −1.7 |
| Cxcr6 | Chemokine (C-X-C motif) receptor 6 | NM_030712 | −1.7 |
| Il10ra | Interleukin 10 receptor, alpha | NM_008348 | −1.7 |
| Il1b | Interleukin 1 beta | NM_008361 | −1.6 |
| Tlr2 | Toll-like receptor 2 | NM_011905 | −1.6 |
| Calca | Calcitonin/calcitonin-related polypeptide, alpha | NM_001033954 | −1.6 |
| Cd44 | CD44 antigen | NM_009851 | −1.6 |
| Blr1 | Burkitt/lymphoma receptor 1 | NM_007551 | −1.6 |
| Il2rb | Interleukin 2 receptor, beta chain | NM_008368 | −1.6 |
| Ccr5 | Chemokine (C-C motif) receptor 5 | NM_009917 | −1.5 |
| Masp2 | Mannan-binding lectin serine peptidase 2 | NM_010767 | −1.5 |
| C1qa | Complement component 1, q subcomponent, alpha polypeptide | NM_007572 | −1.5 |
| Il2rg | Inteleukin 2 receptor, gamma chain | NM_013563 | −1.5 |
| Cmtm3 | CKLF-like MARVEL transmembrane domain containing 3 | NM_024217 | −1.5 |
| Osmr | Oncostatin M receptor | NM_011019 | 1.5 |
| Csf2rb2 | Colony stimulating factor 2 receptor, beta 2 | NM_007781 | 1.6 |
| Cxcl4 | Chemokine (C-X-C motif) ligand 4 | NM_019932 | 1.6 |
| Chi3l4 | Chitinase 3-like 4 | NM_145126 | 1.7 |
| Il17rb | Interleukin 17 receptor B | AF208109 | 1.8 |
| Cfd | Complement factor D (adipsin) | NM_013459 | 1.9 |
| Cd163 | CD163 antigen | NM_053094 | 1.9 |
| Cxcl7 | Chemokine (C-X-C motif) ligand 7 | NM_023785 | 2.1 |
| Serpina1b | Serine (or cysteine) preptidase inhibitor, clade A, member 1b | BC037008 | 2.2 |
| Hc | Haemolytic complement | NM_010406 | 2.7 |
| Ccbp2 | Chemokine binding protein 2 | NM_021609 | 2.8 |
| Grem2 | Gremlin 2 homolog, cystein knot superfamily | NM_011825 | 3.5 |
| Ahsg | Alpha-2-HS-glycoprotein | NM_013465 | 4.2 |
| Chi3l3 | Chitinase 3-like 3 | NM_009892 | 6.4 |