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. Author manuscript; available in PMC: 2013 May 15.
Published in final edited form as: J Immunol. 2012 Apr 9;188(10):5086–5093. doi: 10.4049/jimmunol.1102914

Figure 5.

Figure 5

LPS and Poly (I:C) mediate release of IL-27(p28) in vivo. (A) Survival curves of C57BL/6J (Wt) mice (n=8–12 per group) after i.p. injection with different doses of LPS from E. coli (0111:B4). (B) RT-PCR of IL-27(p28) gene expression in spleen homogenates from Wt mice 6 h after administration of either LPS (10 mg/kg BW i.p., n=6) or Poly (I:C) (10 mg/kg BW i.p., n=5). Sham mice (n=3) received an i.p. injection with PBS. (C) Levels of circulating plasma IL-27(p28) as detected by ELISA after 6 h from the same experiment as shown in (B). *p < 0.05, error bars represent s.e.m.