Figure 1.

Frequencies of CIMP-high, MSI-high, and BRAF mutation in colorectal cancer along bowel subsites. The frequencies of these molecular features increase gradually from rectum to ascending colon. Formal multivariate statistical analyses for linearity and non-linearity were performed as described in MATERIALS AND METHODS and results are shown in Table 4.

CIMP, CpG island methylator phenotype; MSI, microsatellite instability.