Frequencies of CIMP/MSI subtypes of colorectal cancer along bowel subsites. The frequency of CIMP-high MSI-high tumors increased gradually from rectum to ascending colon, while that of CIMP-low/0 MSS tumors decreased gradually from rectum to ascending colon.
CIMP, CpG island methylator phenotype; MSI, microsatellite instability; MSS, microsatellite stable.