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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2011 Nov 4;258(1):145–150. doi: 10.1016/j.taap.2011.10.017

Table 1.

IC50 values for Reactions of Serine Hydrolases with Oxons*

Serine Hydrolase, IC50 (nM)**
Oxon Carboxylesterase 1 Carboxylesterase 2 Monoacylglycerol
lipase
Chlorpyrifos Oxon 0.15 ± 0.05a 0.33 ± 0.05a 5.1 ± 3.7b
Paraoxon 0.38 ± 0.10a 6.2 ± 0.3b 120 ± 40c
Methyl Paraoxon 4.8 ± 0.2b 220 ± 50c 1600 ± 960d
*

All reactions were carried out at 37°C with enzyme and inhibitor preincubated for 15 min prior to the addition of substrate.

**

Values are means ± standard deviation of at least 3 independent experiments. All values in the same row or column with different superscripts are significantly different (p< 0.001, ANOVA and Tukey’s post-hoc test).