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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2011 Nov 4;258(1):145–150. doi: 10.1016/j.taap.2011.10.017

Table 2.

Bimolecular Rate Constants for Reactions of Serine Hydrolases with Oxons

Serine Hydrolase, kinact/KI(M−1·s−1)*
Oxon Carboxylesterase 1 Carboxylesterase 2 Monoacylglycerol
lipase
Chlorpyrifos Oxon 2.0 (±0.50) × 107 4.4 (±2.7) × 105 1.4 (±0.37) × 104
Paraoxon 1.9 (±0.48) × 106 3.4 (±2.3) × 104 N.D.
Methyl Paraoxon 1.2 (±0.57) × 105 8.1 (±2.8) × 102 N.D.
*

Values are means ± standard deviation of at least 6 independent experiments. All values have p< 0.001 when compared with values in the same row or column. N.D., not determined (insufficient inhibition to accurately measure).