Table I.
Study assessments and median testing time (minutes) at baseline (week 0) in pilot study of donepezil in childhood BT survivors
| Neuropsychologic Domain | Measure | Week | Expected testing time# | Actual testing time (min) at wk 0 (range) | |||
|---|---|---|---|---|---|---|---|
|
| |||||||
| 0 | 12 | 24 | 36 | ||||
| Global Intelligence | Wechsler Abbreviated Scale of Intelligence (WASI)(44) | X | X | 30 | 40 (35–57) | ||
| Executive Function | Delis-Kaplan Executive Function System (D-KEFS)(21): subtests (Tower Test; Letter Fluency; Color-Word Interference-Inhibition; Sorting) | X | X | X | X | 65 | 63 (41–90) |
| Memory | Wide Range Assessment of Memory and Learning, 2nd Edition (WRAML-2)(22) | X | X | X | X | 45 | 25 (17–60) 12 (2–15)) |
| Sustained Attention and Concentration | Conners Continuous Performance Test (CPT) II (23) | X | X | X | X | 14 | 22 (19–30) |
| Processing Speed | Wechsler Intelligence Scale for Children – IV (WISC-IV) Symbol Search subtest (24) | X | X | X | X | 5 | 4 (2–11) |
| Achievement | Woodcock Reading Mastery Test(25) | X | X | 25 | 28 (9–45) | ||
| Woodcock Johnson III Calculations (26) | X | X | 10 | 10 (5–13) | |||
| HRQL | Pediatric Quality of Life Inventory, version 4.0 (Peds QL™ 4.0)(30) | X | X | X | X | 6 (4–9) | |
| Quality of Life Assessment (QUOLA)(31) | X | X | X | X | 13 (8–25) | ||
| Total testing time for Child | 224 (167–278) | ||||||
| Parent Report of Cognition and Behavior | |||||||
| HRQL of child | Peds QL™ 4.0 | X | X | X | X | ||
| Executive Function of Child | Behavior Rating Inventory of Executive Functioning (BRIEF)(27): The Parent form | X | X | X | X | ||
| Behavioral Adjustment and Social Competency of Child | Behavior Assessment System for Children, Second Edition (BASC-2) (28) | X | X | X | X | ||
| Life Events Checklist: A 5 item assessment of major life events in the past year | X | X | |||||
| Family Impact | Pediatric Inventory for Parents (PIP): A 42 item evaluation of parenting stress related to the child’s chronic illness. | X | X | ||||
#
Estimates for completion of specified battery, based on test manufacturer indicated times: 195 min. for full battery; 130 min. for abbreviated battery