Table IV.
Neurocognitive functioning at baseline and 24 week change on Donepezil
| Neurocognitive Test | Baseline Least Squares Mean^ | Effect Size (SE)† Baseline to Week 24 | p-value |
|---|---|---|---|
| Global Intelligence* | |||
| WASI Verbal IQ | 89.8 | −0.06 (0.18) | 0.7365 |
| WASI Performance IQ | 83.4 | 0.05 (0.12) | 0.6563 |
| WASI Full scale IQ | 85.6 | −0.01 (0.09) | 0.9016 |
| Executive Functioning** | |||
| D-KEFS Tower Total | 8.3 | 1.14 (0.27) | 0.0003 |
| D-KEFS Towers Time Ratio | 7.7 | 0.74 (0.27) | 0.0131 |
| D-KEFS Letter Fluency | 6.6 | −0.02 (0.21) | 0.9250 |
| D-KEFS Color/Word Inhibition | 8.6 | 0.62 (0.28) | 0.0408 |
| D-KEFS Sorting | 4.9 | 0.24 (0.19) | 0.2330 |
| Memory | |||
| WRAML-2 Visual Memory* | 81.5 | 0.67 (0.22) | 0.0070 |
| WRAML-2 Verbal Learning*** | 7.7 | 0.32 (0.21) | 0.1495 |
| WRAML-2 Number/Letter*** | 7.8 | 0.39 (0.15) | 0.0180 |
| Sustained Attention and Concentration*** | |||
| CPT II Omissions@ | 62.1 | −0.59 (0.49) | 0.2366 |
| CPT II Commissions@ | 49.1 | −0.15 (0.25) | 0.5523 |
| CPT II Response Style@ | 57.0 | −0.67 (0.46) | 0.1531 |
| CPT II Detectability(d′)@ | 56.6 | −0.65 (0.35) | 0.0731 |
| Processing Speed** | |||
| WISC-IV Symbol Search | 4.8 | 0.45 (0.27) | 0.1048 |
^
Model is adjusted for baseline IQ and age at radiation therapy;
†
Effect size calculated as difference score (adjusted difference between 24 weeks and baseline) divided by test standard deviation;
*
mean=100, s.d.=15;
**
mean=10, s.d.=3;
***
mean=50, s.d.=10;
@
CPT is reverse scored such that negative effect sizes represent improvement;
WASI=Weschler Abbreviated Scale of Intelligence; IQ= intelligence quotient; D-KEFS= Dellis-Kaplan Executive Function Scale; WRAML-2= Wide Range Assessment of Memory and Learning, 2nd Edition (WRAML-2); CPT II= Connor’s Performance Test II; WISC-IV=Wechsler Intelligence Scale for Children, 4th Edition