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. Author manuscript; available in PMC: 2013 Mar 30.
Published in final edited form as: Cell. 2012 Mar 30;149(1):22–35. doi: 10.1016/j.cell.2012.03.003

Figure 2.

Figure 2

A. The Myc-Max heterodimer is shown to interact with key co-factors such as TFIIH that triggers transcriptional elongation or TRRAP that recruits the GCN5, which acetylates histone, permitting transcription of target genes. B. Myc-Max also mediates gene repression. Miz-1 is shown tethered to the INR element to regulate transcription of target genes, which could be silenced by Myc displacement of NPM, a Miz-1 cofactor, or by Myc induction of the ribosomal protein RPL23, which retains NPM in the nucleolus, keeping it away from Miz-1.