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. Author manuscript; available in PMC: 2013 Mar 30.
Published in final edited form as: Cell. 2012 Mar 30;149(1):22–35. doi: 10.1016/j.cell.2012.03.003

Figure 4.

Figure 4

Myc-Max is shown bound to E-box driven genes, which could also be regulated by other E-box transcription factors, such as the carbohydrate response element binding protein (ChREBP), sterol response element binding protein (SREBP), nuclear respiratory factor 1 (NRF1), circadian transcription factor Clock (and Bmal), and hypoxia inducible factor (HIF). The non-Myc E-box transcription factors regulate genes involved in metabolism, which is maintained for cellular homeostasis when cells are not proliferating. Upon activation of MYC and elevated levels of Myc, mass action favors the binding of Myc-Max to E-box genes to regulate metabolism and genes involved in ribosomal biogenesis and cell mass accumulation. This model suggests that resting cells express metabolic genes through ‘homeostatic’ E-box transcription factors, which regulate a set of genes that overlaps with Myc target genes that are expressed when cells are stimulate to grow and proliferate.