Table 1.
Model parameters for the ethanol PBPK.
| Physiological parameters of the model PBPK for ethanol | |
|
| |
| Body weight | 70 |
| Cardiac output (L/h/kg)0.75 | 18 |
| Alveolar ventilation (L/h/kg)0.75 | 18 |
| Absorbed fraction | 0.62 |
|
| |
| Fraction of cardiac output to each compartment | |
|
| |
| Fat | 0.05 |
| Liver | 0.25 |
| Rapidly perfused | 0.39 |
| Slowly perfused | 0.19 |
| Brain | 0.12 |
|
| |
| Total | 1.00 |
|
| |
| Fraction of body volume compartments | |
|
| |
| Fat | 0.213 |
| Liver | 0.0257 |
| Rapidly perfused | 0.0443 |
| Slowly perfused | 0.607 |
| Brain | 0.02 |
|
| |
| Total | 0.91 |
|
| |
| Physicochemical and metabolic parameters | |
|
| |
| Partition coefficients | |
| Blood: air | 2280 |
| Fat: air | 226 |
| Liver: air | 1730 |
| Rapidly perfused: air | 2030 |
| Slowly perfused: air | 1710 |
| Brain: air | 1870 |
|
| |
| Liver metabolic parameter | |
|
| |
| Metabolism rate (mg/h/kg)0.75 | 359.5 |
| Affinity constant (mg/L) | 82.1 |