Figure 4.

FIB-1::GFP dynamic pattern changes during development. (a) An embryo at the 40–50 cell stage, arrowheads indicate strong dots of nucleoli. Faint GFP outlines are the nucleus. (b) Intestinal cells at the larval stage, arrowheads indicate circles that may represent a GC region. (c) Intestinal cells at the young adult stage, arrowheads indicate GFP foci close to the nucleoli. These may be like the Cajal body or perinucleolar compartment (PNC) in human cells. (d) Intestinal cells of an aged worm, arrowheads indicate FIB-1::GFP fragments, possibly a sign that ribosome biogenesis was aberrant in these cells. The scale bar represents 10 μm.