Table 1. Demographics of Study Cohort of Survivors, by Baseline Physical Functioning (n= 623).
Data for the entire cohort of incident severe sepsis hospitalizations are in eTable 1, and on risk factors for cognitive impairments are presented in eTable 2.
| No Limits | Mild / Moderate Limits | Severe Limits | |
|---|---|---|---|
| n | 269 | 195 | 159 |
| Male (%) | 143 (53%) | 92 (47%) | 46 (29%) |
| Black (%) | 49 (18%) | 41 (21%) | 38 (24%) |
| Hispanic (%) | 19 (7%) | 12 (6%) | 13 (8%) |
| Age at Sepsis (mean (SD), years) | 75.8 (7.5) | 76.7 (9.5) | 79.1 (9.6) |
| Length of Stay (mean (SD), days) | 11.4 (10.7) | 11.3 (11.2) | 8.5 (6.3) |
| Required Mechanical Ventilation | 64 (23%) | 32 (16%) | 27 (17%) |
| Required Dialysis | 9 (3.4%) | 6 (3.1%) | 12 (7.6%) |
| Used an Intensive Care Unit | 137 (51%) | 75 (38%) | 57 (36%) |
| Underwent Major Surgery | 73 (27%) | 39 (20%) | 15 (9%) |
| Charlson Score (mean (SD)) | 1.69 (1.42) | 1.96 (1.64) | 2.11 (1.41) |
| Organ Dysfunction Score (mean (SD)) | 1.15 (0.39) | 1.16 (0.45) | 1.11 (0.34) |
| Acute Cardiovascular Dysfunction | 60 (22%) | 62 (32%) | 45 (28%) |
| Acute Neurologic Dysfunction | 19 (7%) | 20 (10%) | 17 (11%) |
| Acute Hematologic Dysfunction | 61 (23%) | 34 (17%) | 27 (17%) |
| Acute Hepatic Dysfunction | 2 (1%) | 0 (0%) | 1 (1%) |
| Acute Renal Dysfunction | 103 (38%) | 79 (41%) | 60 (38%) |
| Acute Respiratory Dysfunction | 64 (24%) | 32 (16%) | 27 (17%) |
| Baseline Cognition Normal | 254 (94%) | 182 (93%) | 105 (66%) |
| Baseline Mild Cognitive Impairment | 15 (5.6%) | 9 (4.6%) | 20 (12.6%) |
| Baseline Moderate/Severe Cognitive Impairment | 0 (0.0%) | 4 (2.1%) | 34 (21.4%) |
| Baseline ADL Deficiencies (mean (SD)) | 0 (0) | 1.3 (0.9) | 4.0 (1.7) |
| Baseline IADL Deficiencies (mean (SD)) | 0 (0) | 0.5 (0.7) | 3.0 (1.5) |
| Proxy Respondent at Baseline | 9 (3%) | 22 (11%) | 59 (37%) |
| Proxy Respondent at First Post-Sepsis Survey | 46 (17%) | 47 (24%) | 87 (55%) |