Table 1.
Demographic and Clinical data
| Sex | Age at autopsy (y) | First stroke (age,y) | Type of seizure (age,y) | Education level (y) | Karnofsky Performance scale (age,y) | GNP (age,y) | Memory difficulties (age,y) | Headaches (age,y) | MRI findings | Autoptic findings | Other features | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P1 | F | 37 | 31 | Complex extratemporal partial seizures: occipital (31) | 18 | 80: normal activity with effort; some signs/symptoms (33) | 0.57 (31); 0.71 (35) | Yes (31) | Migraine (after 33) | Multiple infarcts (temporal and occipital cortex) | Multiple infarcts in the temporal and the occipital cortex, subtle neuronal loss in the CA4 region of hippocampus | Hearing loss, facial paresthesia, neuropathy, muscle weakness, fatigue, myoclonus |
| P2 | M | 39 | 27 | Generalized seizures (27) | 12 | 40: disable; require special care and assistance (34) | 2.4 (34) | Yes (NA) | Non-migrainous headache (27) | Extensive anterior frontal, parietal, temporal and occipital white matter/cortical infarcts; moderate cerebral and cerebellar atrophy | Multifocal infarcts (frontal, temporal, parietal, occipital cortex) with focal microcystic formations; mild atherosclerotic vascular disease | Diabetes mellitus, muscle weakness, exercise intolerance, cramps, myoclonus, hearing loss, behavioral problems, incoordination, aphasia, alcohol and cocaine abuse in adolescence |
| P3 | F | 35 | 32 | Generalized seizures (32) | 12 | 30: severely disable (35) | 2.8 (35) | Yes (33) | Migraine (32) | Temporal, posterior frontal, parietal and occipital infarcts; cerebral and cerebellar atrophy | Cerebral atrophy, multifocal infarcts of variable ages in bilateral temporal, frontal, parietal and occipital lobes; laminar necrosis in frontal cortex | Aphasia, ataxia, behavioral problems, gestational diabetes, exercise intolerance, cramps, myoclonus, hearing loss, hirsutism, pigmentary retinopathy |
| P4 | F | 38 | 17 | Partial seizures: occipital (17) | 12 | 60: requires occasional assistance, but is able to care for most needs (33) | 2.5 (31); 3.0 (34) | Yes (17) | Migraine (17) | Pons, bilateral temporal, bilateral hippocampi, bilateral parietal, left occipital, right frontal lobe cortical infarcts | Multifocal infarcts of variable ages in bilateral temporal, bilateral parietal, left occipital, and right frontal lobes, bilateral microscopic infarcts in subiculum; mild neuronal loss in CA4 of hippocampus | Diabetes mellitus, proximal muscle weakness, exercise intolerance, myoclonus, hearing loss, peripheral neuropathy, retinopathy, agnosia, dyspraxia, ataxia, ptosis |
NA: data not available; y: years; GNP: global neuropsychological score.