Figure 1.

Redox signaling in T₃ liver preconditioning is mediated by activation of transcription factors nuclear factor-κB, activating protein 1, signal transducer and activator of transcription 3, and nuclear factor erythroid 2-related factor 2 triggering antioxidant, anti-apoptotic, acute-phase and proliferative responses. AP-1: Activating protein 1; APP: Acute-phase protein; CYP2E1: Cytochrome P450 isoform 2E1; GCLC: Glutamate cysteine ligase catalytic subunit; GST: Glutathione-S-transferase; HO-1: Heme-oxygenase 1; IKK: Inhibitor of IκB kinase; iNOS: Inducible nitric oxide synthase; IL-6: Interleukin-6; IL-6R: Interleukin-6 receptor; JAK: Janus kinase; JNK: c-Jun N-terminal kinase; MnSOD: Manganese superoxide dismutase; MRP: Multidrug resistance protein; NF-κB: Nuclear factor-κB; NQO-1: NAD(P)H quinone oxidoreductase 1; Nrf2: Nuclear factor-erythroid 2 related factor 2; QO₂: Rate of oxygen consumption; ROS: Reactive oxygen species; STAT3: Signal transducer and activator of transcription 3; Thr: Thioredoxin; TNF-α: Tumor necrosis factor-α; TNFR1: Tumor necrosis factor-α receptor 1; UDPGT: UDP-glucuronyl transferase.