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. 2012 Mar 12;33(7):838–845. doi: 10.1093/eurheartj/ehr452

Figure 4.

Figure 4

Gene transfer. Viral vectors bind to cell surface receptors, initiating endocytosis. Once internalized, the viral particles avoid degradation and travel to ‘dock’ on the nuclear envelope membrane pores, and the genome is delivered into the cell nucleus. (Created by the US National Library of Medicine.) From Lyon AR, Sato M, Hajjar RJ, Samulski RJ, Harding SE. Gene therapy: targeting the myocardium. Heart 2008;94:89–99.