Table 2.
Parameters of mouse plaque vulnerability
| Parameters | Vehicle-treated mice (n = 6) | JWH-133-treated mice (n = 7) | P-value |
|---|---|---|---|
| Carotid LSS | |||
| Oil-red-O, ×103 μm2 | 179.5 (24.7–198.0) | 22.1 (15.4–49.2) | 0.18 |
| Macrophage+ area, % | 5.1 (0.1–8.7) | 0.6 (0.1–2.4) | 0.42 |
| Neutrophils/mm2 | 1.7 (0.02–4.5) | 0.06 (0.04–0.19) | 0.52 |
| Total collagen, % | 18.1 (17.7–26.7) | 12.9 (7.0–15.2) | 0.05 |
| MMP-9, % | 1.6 (0.4–2.8) | 0.09 (0.05–1.11) | 0.17 |
| Carotid OSS | |||
| Oil-red-O, ×103 μm2 | 155.3 (101.0–163.5) | 179.8 (148.9–212.2) | 0.37 |
| Macrophage+ area, % | 2.6 (0.6–7.4) | 3.6 (1.3–5.5) | 0.68 |
| Neutrophils/mm2 | 1.3 (0.5–3.2) | 0.65 (0.1–1.4) | 0.22 |
| Total collagen, % | 10.4 (9.6–12.9) | 15.2 (10.9–20.5) | 0.17 |
| MMP-9, % | 3.9 (0.5–6.8) | 0.4 (0.2–1.5) | 0.04 |
| Aortic roots | |||
| Oil-red-O, ×103 μm2 | 172.2 (140.0–203.2) | 223.6 (161.2–239.3) | 0.10 |
| Macrophage+ area, % | 17.3 (15.0–20.2) | 18.9 (13.4–19.3) | 0.94 |
| Neutrophils/mm2 | 7.2 (4.7–18.2) | 2.4 (2.0–19.3) | 0.01 |
| Total collagen, % | 33.0 (18.4–40.0) | 39.3 (33.7–55.6) | 0.07 |
| MMP-9, % | 6.0 (4.3–11.9) | 1.9 (1.6–2.3) | 0.001 |
Data are expressed as median (inter-quartile range). MMP, matrix metalloproteinase.