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The Kaplan–Meier plot for coronary heart disease and the number of risk alleles carried. Compared with the reference group of those with no risk alleles, the age- and practice-adjusted hazard ratio for those with only one allele = 1.19 (0.78–1.84), P = 0.42, for any two alleles = 1.79 (1.16–2.75), P = 0.008, and for three and four alleles = 1.75 (1.07–2.85) P = 0.025. Overall P = 0.005.
