Figure 3.
Neurologic scores and infarct volume after 90 minutes of transient middle cerebral artery occlusion in the control (CON), delayed remote limb ischemic postconditioning (DRIPost), 5-HD (KATP blocker, 20 mg/kg, intravenously), DIAZ (KATP opening, 5 mg/kg, intravenously), 0.9% (w/v) saline, dimethyl sulfoxide (DMSO) groups in part 2 (n=8 for each). DRIPost was performed with bilateral femoral artery occlusion/reperfusion at 6 hours after reperfusion. Neurologic scores are presented as the median (range); Date for infarct volumes are expressed as the mean±s.d. Neurologic scores were evaluated at 24 hours (A), 48 hours (B), and 72 hours (C) after reperfusion using the Garcia scoring system. (D) Representative 2,3,5-triphenyltetrazolium chloride staining of the cerebral infarct in the rat brain at 72 hours after reperfusion. (E) Statistical analysis of the percentage of infarct volume was determined for each study group. #P<0.05 versus Con group. *P<0.05 versus DRIPost group. DIAZ, diazoxide; 5-HD, 5-hydroxydecanote; NS, normal saline.