Table 2. Comparison of each parameter of the gas-PET study between patients with severe or mild WMLs in the brain.
| Severe WMLs group (n=9) | Mild WMLs group (n=9) | P | |
|---|---|---|---|
| Frontal cortex | |||
| CBF (mL/100 g per minute) | 35.7±9.0 | 37.8±8.5 | 0.630 |
| CBV (mL/100 g) | 3.0±0.9 | 3.0±0.6 | 0.969 |
| OEF (%) | 54.1±14.7 | 48.3±5.2 | 0.275 |
| CMRO2 (mL/100 g per minute) | 3.24±0.49 | 3.26±0.73 | 0.946 |
| Parietal cortex | |||
| CBF | 40.2±6.9 | 44.1±11.6 | 0.403 |
| CBV | 2.8±0.7 | 3.1±0.5 | 0.284 |
| OEF | 50.6±6.9 | 46.3±4.9 | 0.146 |
| CMRO2 | 3.53±0.35 | 3.62±0.80 | 0.743 |
| Occipital cortex | |||
| CBF | 40.4±8.6 | 47.4±16.1 | 0.266 |
| CBV | 3.5±0.9 | 3.7±1.5 | 0.745 |
| OEF | 55.8±8.8 | 50.4±4.5 | 0.116 |
| CMRO2 | 3.88±0.63 | 4.22±1.16 | 0.442 |
| Basal ganglia | |||
| CBF | 45.1±9.4 | 49.5±13.1 | 0.426 |
| CBV | 2.3±0.7 | 2.5±0.5 | 0.521 |
| OEF | 52.8±7.9 | 50.5±6.3 | 0.505 |
| CMRO2 | 4.14±0.66 | 4.43±0.90 | 0.441 |
| Centrum semiovale | |||
| CBF | 20.6±4.4 | 29.9±8.2 | 0.008 |
| CBV | 1.2±0.4 | 1.4±0.3 | 0.217 |
| OEF | 55.2±7.4 | 46.7±5.3 | 0.013 |
| CMRO2 | 1.95±0.41 | 2.44±0.42 | 0.025 |
CBF, cerebral blood flow; CBV, cerebral blood volume; CMRO2, cerebral metabolic rate of oxygen; OEF, oxygen extraction fraction; PET, positron emission tomography; WMLs, white-matter lesions.
P value by Mann–Whitney U-test.