Figure 2.
(A) Time course of cerebral pH (
) during the 3-nitropropionic acid (3NP) intoxication protocol showing a significant increase at day 3 (D3), followed by a significant decrease on day 5 (D5). pH changes appear correlated with succinate dehydrogenase (SDH) inhibition (
); (B) magnetic resonance imaging (MRI) images acquired in one rat during the intoxication protocol, demonstrating the absence of MRI-visible lesion before D5 and major striatal lesions at D5.
