Fig. 1.
Experimental dosing regimen. Wild-type (PPARF/F) mice and intestinal epithelial cell (IEpC) peroxisome proliferator-activated receptor (PPAR)-δ null (PPARδΔIEpC) mice consuming a 5% corn oil (CO) or a 1% corn oil + 4% fish oil (FO) diet were acclimated to experimental diets for 14 days prior to injection of azoxymethane (AOM, 7.5 mg/kg body wt ip). Subsequently, mice were exposed to 3 cycles of dextran sodium sulfate (DSS, 1% wt/wt via drinking water). Mice were euthanized 12 wk after completion of the final DSS cycle.