Figure 7.
Antitumor memory responses induced by Ad/scIL-12-B7TM. Groups of BALB/c mice (n = 5–6) that had been previously treated with Ad/scIL-12-B7TM or Ad/scIL-12 and eliminated the original tumors were rechallenged (a) subcutaneously with 1 × 105 CT26 or (b) intravenously with 2 × 105 CT26 cells. Age-matched naive BALB/c mice were included as controls. In a, the results are the mean ± SD for those mice with measurable tumors. In b, the mean and individual metastatic foci of each group are presented. IL, interleukin.