FIGURE 3.
Heterogeneous Δψp responses of individual cells to glucose. Cells were preincubated in buffer A in the presence of 2.8 mm glucose and transferred to glucose-free medium immediately before imaging. Where indicated, 8 mm glucose (glu), 640 ng/ml oligomycin (oligo) were added. KCl was added to 25 mm. Representative Δψp and [Ca2+]c responses of three individual cells are shown following addition of 8 mm glucose. Cell a had a long latent period before initiating Δψp and [Ca2+]c oscillations. Cell b showed an initial oscillation followed by a latent period. Cell c was quiescent after the initial oscillation until oligomycin was added.