Table 5.
Percentage change in median GH AUC2h by dose group following a single subcutaneous dose of pasireotide or placebo
| Dose (μg) | n | Change in median GH AUC2h, % | Range of change in median GH AUC2h, % min, max |
|---|---|---|---|
| 0 | 18 | −11.9 | −74.4, 170.0 |
| 1 | 6 | 8.1 | −76.3, 33.6 |
| 2.5 | 6 | 23.8 | −41.5, 125.8 |
| 10 | 6 | 1.0 | −26.1, 70.4 |
| 30 | 6 | −45.3 | −66.5, 24.7 |
| 100 | 8 | −46.2 | −72.8, 575.9 |
| 200 | 4 | −79.1 | −85.3, −67.9 |
| 300 | 6 | −86.7 | −93.6, −64.9 |
| 600 | 6 | −82.5 | −96.5, −59.6 |
| 1200 | 6 | −95.7 | −97.1, −87.9 |
Abbreviations: AUC, area under the concentration–time curve; GH, growth hormone.