Table 1.

General molecular and prominent functional properties of tetraspanins also expressed in MC.

Name: CD, HGNC; OMIM No.	Gene: accession, location	Protein: accession, size	Function (in human or murine cells)
CD9, TSPAN29; *143030	Human: *928, 12p13.3 Mouse: *125276 F3	Human: NP_001760, 228 aa, 25.4 kDa Mouse: NP_031683, 226 aa, 25.3 kDa	Fusion of gametes (Kaji et al., 2000), myoblasts (Tachibana and Hemler, 1999), and virus infected cells (Loffler et al., 1997); represses tumor cell motility (Miyake et al., 1991; Ikeyama et al., 1993); prevents monocyte fusion (Takeda et al., 2003); formation of paranodal nerve junctions (Ishibashi et al., 2004); MHC II multimerization (Unternaehrer et al., 2007). In MC: IL-16 receptor in MC and other cells (Qi et al., 2006); might promote FcεRI (Peng et al., 2011) and FcγR signaling (Huang et al., 1992).
CD63, TSPAN30; *155740	Human: *967, 12q12-q13 Mouse: *1251210 D3	Human A: NP_001771, 238 aa, 25.6 kDa; Human B: NP_001035123, 236 aa, 25.4 kDa Mouse: NP_031679, 238 aa, 25.8 kDa	Promotes tumor cell motility and migration (Radford et al., 1997); regulates endosomal sorting (van Niel et al., 2011); cofactor for leukocyte recruitment by endothelial P-selectin (Doyle et al., 2011); internalization of H,K-ATPase beta-subunit in gastric parietal cells (Duffield et al., 2003); neutrophil activation and adhesion (Skubitz et al., 1996). Promotes MC adhesion and degranulation (Kraft et al., 2005).
CD81, TSPAN28; *186845	Human: *975, 11p15.5 Mouse: *125207 F5	Human: NP_004347, 236 aa, 25.8 kDa Mouse: NP_598416, 236 aa, 25.8 kDa	Promotes CD19 expression/antibody production (van Zelm et al., 2010); T-cell adhesion and co-stimulation (Todd et al., 1996; Sagi et al., 2012); cell migration (Quast et al., 2011); virus entry (Pileri et al., 1998); Plasmodium infection (Silvie et al., 2003); prevents monocyte fusion (Takeda et al., 2003); Promotes FcεRI dependent degranulation (Fleming et al., 1997).
CD151, TSPAN24; *602243	Human: *977, 11p15.5 Mouse: *124767 F5	Human: NP_004348, NP_620599$, 253 aa, 28.3 kDa Mouse: NP_001104520, 253 aa, 28.3 kDa	Regulates integrin traffic and promotes cell migration (Liu et al., 2007); enables platelet aggregation by integrin outside-in signaling (Lau et al., 2004); strengthens adhesion to laminin-1 (Lammerding et al., 2003); inhibits T-cell proliferation (Wright et al., 2004); strengthens podocyte binding to glomerular basement membrane (Sachs et al., 2012).

Accession numbers of the respective NCBI databases (OMIM, Gene, or Protein reference sequence) are given. ^$Results of a transcript that lacks an alternate segment in the 5′ UTR.