Table 2.
Upgrade rates after flat epithelial atypia (FEA) diagnosis on vacuum-assisted or core needle biopsy and excision
| Author, year [ref.] | Needle biopsies, n | FEA lesions, n (%) | Excisional biopsy, n (%) | DCIS on excision, n (%)a | Invasive carcinoma on excision, n (%) | Total upgrade rate, n (%) |
|---|---|---|---|---|---|---|
| Guerra-Wallace et al. 2004 [87] | 7,820 | 60 (0.8) | 60 (100) | 4 (6.7) | 3 (5) | 7 (11.7) |
| Kanji et al. 2007 [40] | 900 | 14 (1.6) | 12 (85.7) | 1 (8.3) | 2 (16.7) | 3 (25) |
| Martel et al. 2007 [41] | 1,751 | 63 (3.6) | 55 (87.3) | 0 (0) | 7 (12.7) | 7 (12.7) |
| Chivukula et al. 2009 [36] | 8,054 | 39 (0.5) | 35 (89.7) | 3 (8.6) | 2 (5.7) | 5 (14.3) |
| Piubello et al. 2009 [88] | 875 | 33 (3.8) | 20 (60.6) | 0 (0) | 0 (0) | 0 (0) |
| Hayes et al. 2009 [89] | 1,829 | 8 (0.4) | 8 (100) | 1 (12.5) | 0 (0) | 1 (12.5) |
| Noel et al. 2006 [90] | ND | 62 | 20 (32.3) | 0 (0) | 0 (0) | 0 (0) |
| Noske et al. 2010 [91] | 1,845 | 43 (2.3) | 30 (69.8) | 2 (6.7) | 0 (0) | 2 (6.7) |
| Ingegnoli et al. 2010 [92] | 476 | 15 (3.2) | 15 (100) | 1 (6.7) | 0 (0) | 1 (6.7) |
| Total | 18,525 | 337 (2.6) | 255 (75.7) | 12 (4.7) | 14 (5.5) | 26 (10.2) |
a
Lobular neoplasia and DCIS are not distinguished.
FEA = Flat epithelial atypia; DCIS = ductal carcinoma in situ; ND = not determined.