Figure 1.

The effect of increasing concentrations of K201 on cardiac mechanical function. (A) Representative pressure and volume traces before and after perfusion with increasing concentrations (0.3, 1 and 3 µmol·L⁻¹) of K201. (B) (i) HR in paced vehicle control (n= 4) and unpaced K201 (n= 8) hearts, expressed as a % of baseline values. Vehicle controls were paced to match HRs recorded at the end of the perfusion period for each concentration of K201. Indices of contractility [B (ii & iii)] and relaxation [C (iii)] are expressed as a % of baseline values. (D) (i) Representative PV loops from time points shown in (A), demonstrating concentration-dependent changes in ESV [D (ii)], SV [D (iii)], EF [D (iv)] and SW [D (v)]. *P < 0.05, significant differences between groups as shown.