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Influence of elevated [Ca2+]o on isolated working heart contractile function. Volume (A, B, G) and contractility indices (C, D) demonstrating sustained positive inotropic effect of increasing [Ca2+]o from 2.5 mmol·L−1 to 4.5 mmol·L−1. HR (E), coronary flow (F) and end diastolic volume (H) were not significantly altered. *P < 0.05, significant differences between groups as shown.
