Table 1.

Left ventricular functional indices from unpaced isolated working rabbit hearts treated with K201

	Pre-K201 (n= 8)	0.3 µmol·L−1K201 (n= 8)	1 µmol·L−1K201 (n= 8)	3 µmol·L−1K201 (n= 8)
Parameter
HR (beats·min−1)	204 ± 3	201 ± 4	190 ± 5*	177 ± 8**
Systolic
PP (mmHg)	98.1 ± 1.5	97.3 ± 2.1	93.4 ± 2.2*	89.4 ± 1.9**
dP/dtmax (mmHg·s−1)	1916 ± 73	1831 ± 110	1501 ± 115*	1277 ± 93**
EF (%)	66.3 ± 3.3	63.5 ± 3.5	56.3 ± 5.1*	46.8 ± 4.9**
Diastolic
EDP (mmHg)	8.2 ± 1.4	9.1 ± 1.5	9.8 ± 1.6	10.2 ± 1.5
dP/dtmin (mmHg·s−1)	−2077 ± 145	−1987 ± 146	−1787 ± 137	−1523 ± 150
τ (ms)	27.4 ± 2.8	29.0 ± 3.1	37.7 ± 4.6*	49.1 ± 7.1**
Volume
AoF (mL·min−1)	177 ± 14	166 ± 16	135 ± 21*	100 ± 24**
CF (mL·min−1)	67.5 ± 4.5	67.8 ± 4.6	67.9 ± 4.6	67.8 ± 4.7
ESV (mL)	0.63 ± 0.07	0.70 ± 0.10	0.87 ± 0.13	1.06 ± 0.14
EDV (mL)	1.88 ± 0.10	1.88 ± 0.11	1.94 ± 0.14	1.98 ± 0.16
SV (mL)	1.24 ± 0.09	1.19 ± 0.10	1.08 ± 0.12*	0.90 ± 0.12**
SW (mmHg*mL)	85.8 ± 7.1	79.8 ± 8.0	69.9 ± 10.1*	50.8 ± 10.7**

^*P < 0.05, 0.3 µmol·L⁻¹ versus 1 µmol·L⁻¹;

^**P < 0.05, 1 µmol·L⁻¹ versus 3 µmol·L⁻¹.