Figure 6.

The mechanisms of the antioxidant effect of azelnidipine (Azel) and the effects of Azel on CYP metabolism and fibrogenesis in mice with CCl₄-induced liver injury. The groups are the same as the CCl₄ groups shown in Figure 4. mRNA (A) and protein (B) expression of ROS-generating enzymes, ACOX1, Nox2. mRNA (C) and protein (D) expression of ROS-eliminating enzymes, catalase, GPx-1, SOD-1, SOD-2 and (E) CYP2E1 and CYP2Bs protein expression. *P < 0.05 and **P < 0.01 versus Cont, †P < 0.05 versus CCl₄ alone.