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. 2012 Feb;165(4b):1034–1045. doi: 10.1111/j.1476-5381.2011.01515.x

Figure 4.

Figure 4

Effect of unilateral injection of the mGlu4 positive allosteric modulator, PHCCC (A,C,E) or the mGlu7 allosteric modulator, AMN082 (B,D,F) in the SNpr on reversal of akinesia in the reserpine-treated rat. (A,B) Time-course of rotational activity induced by the maximally effective dose of 75 nmol PHCCC or 100 nmol AMN082. Data are mean ± SEM (n= 8, PHCCC or n= 6, AMN082). *P < 0.05, **P < 0.01, ***P < 0.001, significantly different from vehicle. (C,D) Effect of increasing doses of PHCCC or AMN082 on total rotational activity over 60 min. Data are mean ± SEM (n= 8, PHCCC or n= 6 AMN082). *P < 0.05, **P < 0.01, significantly different from vehicle; #P < 0.05, significantly different from 3 nmol doses. (E,F) Effect of pre-treatment with CPPG (75 nmol) on the rotational response to PHCCC (75 nmol) or AMN082 (100 nmol). Data are mean ± SEM (n= 8, PHCCC or n= 6 AMN082). **P < 0.01, significantly different from vehicle pre-treatment.