Figure 5.

Effect of unilateral injection of the mGlu₈ agonist (S)-3,4-DCPG, in the SNpr on reversal of akinesia in the reserpine-treated rat. (A) Time-course of locomotor activity induced by the maximally effective dose of 300 nmol (S)-3,4-DCPG. Data are mean ± SEM (n= 5). ***P < 0.001, significantly different from vehicle. (B) Effect of increasing doses of (S)-3,4-DCPG on total rotational activity over 60 min. Data are mean ± SEM (n= 4). *P < 0.05, significantly different from vehicle. (C) Effect of pre-treatment with CPPG (75 nmol) on the rotational response to (S)-3,4-DCPG (300 nmol). Data are mean ± SEM (n= 5).