Table 1.

Semi-quantitative immunohistochemical analysis of dorsal skin (number of rats with positive immunostaining)

Treatment	No of rats	CD34	ED-1	TGFβ1	S100A4	α-SMA	P-4-OH	TIMP-1
Saline	5	(+) [sc and ECs]	(±)	(−)	(+) [sc]	(−)	(±)	(±)
Gadoterate	8	(+) [sc and ECs]	(±)	(−)	(+) [sc]	(−)	(±)	(±)
Gadodiamide	8	(+) [sc and ECs] but ↑ number of sc	(±) = 3	(−) = 2	(+) [sc] but ↑ number of sc	(−)	(±) = 2	(±) = 2
			(++) = 5	(foci) = 2			Foci (++) = 6	Foci (++) = 6
				(+) = 1
				(++) = 3
Gadobenate	7	(+) [sc and ECs]	(±) = 6	(−) = 6	(+) [sc]	(−)	(±)	(±)
			(++) = 1 (focus)	(++) = 1 (focus)
Gadobutrol	7	(+) [sc and ECs]	(±)	(−)	(+) [sc]	(−)	(±)	(±)
Ca-DOTA	6	(+) [sc and ECs]	(±)	(N/A)	(N/A)	(N/A)	(N/A)	(N/A)
Ca-DTPA	6	(+) [sc and ECs]	(±)	(N/A)	(N/A)	(N/A)	(N/A)	(N/A)

‘sc’ indicates spindle cells and ‘ECs’ indicates endothelial cells. −= absence, ±= mild, += moderate, ++= severe, N/A = not available.