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. Author manuscript; available in PMC: 2012 May 7.
Published in final edited form as: Mol Pharm. 2009 Jan-Feb;6(1):29–39. doi: 10.1021/mp800148u

Figure 1.

Figure 1

Dependence of drug flux ratio in the USP 50 mM phosphate buffer versus 15 mM bicarbonate buffer on drug pKa and solubility.

The drug diffusion coefficient is assumed to be 5×10−5 cm2/s.