Figure 4.

TCV-induced protection in EAE is CD8⁺ T cell dependent and TCR Vβ and TH type specific. EAE was induced by the encephalitogenic clone 1AE10 as described. TCV was performed 1 week before EAE induction with different T cell clones: One group of mice were treated with either rat Ig (■) or anti-CD8 (●) 3 days before TCV with 1AE101 (Vβ8.2⁺, TH1); other groups received TCV with 3AD2 (Vβ8.2⁺, TH2) (▵) or 3AF9 (Vβ6⁺, TH1) (▴). Mice in the control group did not receive TCV (⧫). Results are representative of four separate experiments with four mice per group per experiment.