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. 2012 Apr;25(2):215–222. doi: 10.1128/CMR.05028-11

Fig 3.

Fig 3

HPV is efficient at evading recognition. The virus can globally downregulate keratinocyte innate immune sensors and suppress the type I interferon response, which is critical for the control of viral infection. There is no viremia and no virus-induced cell death; hence, there is no inflammation or danger signal to the immune system.