Fig 5.

Associations between CD46 rs7144 genotypes and CD46 receptor protein expression at baseline and CD46 downregulation after ML stimulation in T cells and APCs. CD46 expression (i.e., the mean fluorescence intensity [MFI]) at 0 h (left) and the percent CD46 downregulation after ML stimulation (right) in T cells (A) and APCs (B) is depicted. The data are presented as median values and interquartile ranges. The CD46 rs7144 genotypes included TT (circles), CT (diamonds), and TT (squares). The percent CD46 downregulation after ML stimulation was calculated according to the method by Sakurai et al. (26).