Fig 6.

Dependence of mitochondrial swelling induced by paenilides and cereulides on potassium ion concentrations ranging from 0 to 40 mM in media. RLM (0.5 mg protein ml⁻¹) were incubated in isotonic glutamate-malate medium (pH 7.3) prepared with NaCl plus KCl (120 mM), with various ratios of [K⁺] to [Na⁺]. (A and B) Mitochondrial swelling was induced by the addition of paenilides (4 ng ml⁻¹) (A) or cereulides (5 ng ml⁻¹) (B). The panels show the original traces, typical of three identical experiments using different mitochondrial preparations. (C) Concentration dependence of maximal ΔOD₅₄₀ in response to added paenilides or cereulides with different [K⁺] concentrations in the external medium (shown on the x axis). Mean values and SE from three experiments are shown.