Skip to main content
. 2012 Jun;78(11):3824–3836. doi: 10.1128/AEM.00051-12

Table 3.

Listeria monocytogenes gene groups showing positive or negative enrichment after acid treatment for 5 or 15 min at 37°C

Gene category and protein or protein group No. of genes in group Enrichment in bacteria grown toa:
Log phase
 Stationary phase
7°C
 37°C
 7°C
 37°C
5 min 15 min 5 min 15 min 5 min 15 min 5 min 15 min
Regulons
    CtsR 18 +*** +***
    HrcA 20 +** −** −*
    σB 166 +*** +*** +*** +*** −*** −***
    σH 95 +*** +*** −*** −***
    σL 31 +*
    PrfA 9 +* +***
    CodY 84 −* −*
Functional categoriesb
    Purines, pyrimidines, nucleosides, and nucleotides: pyrimidine ribonucleotide biosynthesis 18 + +* +*
    Amino acid biosynthesis: aspartate family 22 +*
    Amino acid biosynthesis: glutamate family 14 −*** −***
    Cellular processes: chemotaxis and motility 25 +*
    Cellular processes: cell division 24 −** −*
    Cellular processes: adaptations to atypical conditions 19 −*
    Cell envelope: other 37 −**
    Energy metabolism: fermentation 33 −*** −**
    Protein fate: protein folding and stabilization 14 +*** +**
    Amino acid biosynthesis: aromatic amino acid family 70 +** +***
    Energy metabolism: pentose pyruvate dehydrogenase 65 +*** +*** +***
    Energy metabolism: biosynthesis and degredation of polysaccharides 16 +*
    Energy metabolism: sugars 44 +**
    Protein synthesis: ribosomal proteins: synthesis and modification 59 +** +*** +*** +***
    Regulatory functions: other 180 −*** −***
    Transport and binding proteins: carbohydrates, organic alcohols, and acids 110 +*** +** +** +***
    Transport and binding proteins: cations 58 +*
    Viral functions: general 47 +** +** +*** +*** +**
a

Reported changes are based on gene set enrichment analysis. +, genes comprising a group were significantly enriched for higher transcript levels after acid stress relative to the nonstressed control in the same growth phase (i.e., positive enrichment); −, significant enrichment for lower transcript levels after acid stress (i.e., negative enrichment). ***, P < 0.001; **, P < 0.01; *, P < 0.05.

b

Functional categories from The Institute for Genomic Research Comprehensive Microbial Resource (http://cmr.tigr.org). Only functional categories containing ≥10 genes are reported; 74 total functional categories were tested for enrichment, including 39 that contained ≥10 genes.