Table 1.

Susceptibility data and Fks1p and Fks2p phenotypes for the three C. glabrata isolates used in animal experiments^a

Strain	Fks alteration	Microdilution MIC (μg/ml)c												CLSI disk diffusion zone diam (mm) for:
		EUCAST			CLSI			EUCAST-BSAb			CLSI-BSA
		ANF	CSF	MCF	ANF	CSF	MCF	ANF	CSF	MCF	ANF	CSF	MCF	CSF	MCF
S3	None	≤0.03	0.25	≤0.03	0.031	0.031	0.125	1	0.25	1	1	0.25	1	31.8	31.0
		≤0.03	0.25	≤0.03	0.25	0.125	0.064	1	0.25	2
		0.06	0.25	≤0.03	0.25	0.125	0.064	1	0.5	1
		(≤0.042)	(0.25)	(≤0.03)	(0.177)	(0.094)	(0.083)	(1)	(0.333)	(1.333)
R83	Fks2p-S663F	0.5	1	0.06	0.25	0.125	0.25	≥32	≥32	≥32	4	4	8	19.5	22.1
		0.5	1	≤0.03	1	1	1	≥32	≥32	≥32
		0.25	1	≤0.03	2	1	0.5	8	4	16
		(1.083)	(1)	(≤0.042)	(1.083)	(0.708)	(0.583)	(≥24)	(≥22.67)	(≥26.67)
RR24	Fks1p-S629P	4	16	1	4	8	4	≥32	≥32	≥32	≥32	≥32	≥32	17.8	20.0
		4	16	1	2	8	2	≥32	≥32	≥32
		2	≥32	2	4	8	2	≥32	≥32	≥32
		(3.333)	(≥21.333)	(1.333)	(3.333)	(8)	(2.667)	(≥32)	(≥32)	(≥32)

^aEUCAST, EUCAST-BSA, and CLSI tests were each done on three separate occasions, whereas a single run of CLSI-BSA and disk testing was performed.

^bBSA, bovine serum albumin-supplemented susceptibility test growth medium.

^cANF, anidulafungin; CSF, caspofungin; MCF, micafungin. Mean MICs from the three testing occasions, in cases where three tests were administered, are given in parentheses.