Table 2.

Means, medians, and standard deviations for pharmacokinetic parameters

Parametera	Anidulafungin			Caspofungin			Micafungin
	Mean	Median	SD	Mean	Median	SD	Mean	Median	SD
ka (h−1)	4.73	3.14	4.4	10.56	9.15	8.47	11.3	7.04	9.31
SCL (liter/h)	0.0005	0.0005	0.00009	0.0002	0.0001	0.0001	0.0008	0.0008	0.0001
Vc (liter)	0.004	0.003	0.0016	0.002	0.003	0.001	0.0065	0.0036	0.01
kck (h−1)	12.62	12.04	5.23	24.93	26.32	9.6	33.07	31.72	6.77
kkc (h−1)	8.2	8.55	2.37	23.91	32.82	12.55	25.9	24.66	3.99
kcp (h−1)	20.59	22.32	7.46	26.63	33	13.98	8.12	5.78	6.38
kpc (h−1)	17.76	15.58	6.49	28.44	29.41	7.53	18.43	11.9	9.82
Vkidney (liter)	0.004	0.004	0.0007	0.003	0.002	0.002	0.004	0.004	0.001

^aSCL is the clearance (liter/h); V_c and V_kidney are the volumes of central compartment and kidney, respectively (liters); k_a, k_cp, k_pc, k_ck, and k_kc are the first-order rate constants that connect the respective compartments.