Table 4.
Log kill values of different efflux pump KO mutants in the presence and absence of efflux inhibitors
| Strain | Log kill value (log10 CFU/ml)a |
|||
|---|---|---|---|---|
| Pyrrole AZI-533 | AZI-533 + PAβN | Pyrazolone AZI-219 | AZI-219 + verapamil | |
| WT Mtuc | 0.6 | 1.7 | 0 | 1.4 |
| KO1 | 1 | 1.3 | 0 | 0.9 |
| KO5 | 1.9 | 1.6 | 3.5 | >3.5b |
| KO6 | 0.8 | 1.2 | 0 | 1.8 |
| KO7 | 2.1 | 2.4 | 0.6 | 3.1 |
Log kill values for WT M. tuberculosis and the different efflux pump KO mutants at the highest concentration of the compounds tested.
Below the LOQ (limit of quantification).
M. tuberculosis.