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(A) The complete N-terminal sequence of human PDE8A1 is aligned with the mouse PDE8A1 sequence. (B) Sequence of a new splice variant, PDE7A3. The C termini of PDE7A1 and PDE7A3 are aligned. The numbering refers to PDE7A1 sequence. The positions of helices 15 and 16 are shown. (C) Comparison of the splice variants of PDE7A. (D) Northern blot analysis of PDE7A. The Northern blots (CLONTECH human I and II) were probed with a 1,200-bp PDE7A probe.
